Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease

OBJECTIVE: To investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography–mass spectrometry. METHODS: Levels of caffeine and its 11 metabolites in serum from 108 patients with PD and 31 age-matched healthy controls w...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Fujimaki, Motoki, Saiki, Shinji, Li, Yuanzhe, Kaga, Naoko, Taka, Hikari, Hatano, Taku, Ishikawa, Kei-Ichi, Oji, Yutaka, Mori, Akio, Okuzumi, Ayami, Koinuma, Takahiro, Ueno, Shin-Ichi, Imamichi, Yoko, Ueno, Takashi, Miura, Yoshiki, Funayama, Manabu, Hattori, Nobutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791797/
https://ncbi.nlm.nih.gov/pubmed/29298852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000004888
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