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Decreased bioactivity of the guanine nucleotide-binding protein that stimulates adenylate cyclase in hearts from cardiomyopathic Syrian hamsters.

We investigated regulation of cardiac adenylate cyclase in 29-d-old BIO 14.6 Syrian hamsters, which inherit cardiomyopathy as an autosomal recessive trait. Pharmacologic stimulation of adenylate cyclase in cardiac membranes with isoproterenol, fluoride ion, guanine nucleotide, forskolin, and mangano...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Kessler, P D, Cates, A E, Van Dop, C, Feldman, A M
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1989
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303976/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2544625/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114147
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