Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of MAb raised against alpha-rat ANP in two rat models of hypertension, spontaneously hypertensive rats o...

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Pubblicato in:	J Clin Invest
Autori principali:	Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, Morii, N, Sugawara, A, Saito, Y, Shiono, S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2544622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114134
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