Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of MAb raised against alpha-rat ANP in two rat models of hypertension, spontaneously hypertensive rats o...

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Detalhes bibliográficos
Main Authors: Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, Morii, N, Sugawara, A, Saito, Y, Shiono, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303964/
https://ncbi.nlm.nih.gov/pubmed/2544622
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