Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of MAb raised against alpha-rat ANP in two rat models of hypertension, spontaneously hypertensive rats o...

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Publikašuvnnas:	J Clin Invest
Váldodahkkit:	Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, Morii, N, Sugawara, A, Saito, Y, Shiono, S
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Clinical Investigation 1989
Fáttát:	Research Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2544622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114134
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