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Structural and Dynamic Mechanisms for the Function and Inhibition of the M2 Proton Channel From Influenza A Virus

The M2 proton channel from influenza A virus, a prototype for a class of viral ion channels known as viroporins, conducts protons along a chain of water molecules and ionizable side chains, including His37. Recent studies highlight a delicate interplay between protein folding, proton binding and pro...

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Autors principals: Wang, Jun, Qiu, Jade Xiaoyan, Soto, Cinque, DeGrado, William F.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039100/
https://ncbi.nlm.nih.gov/pubmed/21247754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2010.12.002
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