Hearing and vestibular deficits in the Coch(−/−) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder

Two mouse models, the Coch(G88E/G88E) or “knock-in” and the Coch(−/−) or “knock-out” (Coch null), have been developed to study the human late-onset, progressive, sensorineural hearing loss and vestibular dysfunction known as DFNA9. This disorder results from missense and in-frame deletion mutations...

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Hlavní autoři: Jones, Sherri M., Robertson, Nahid G., Given, Shelly, Giersch, Anne B. S., Liberman, M. Charles, Morton, Cynthia C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039082/
https://ncbi.nlm.nih.gov/pubmed/21073934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2010.11.002
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