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Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

Huntingtin (Htt) is a membrane-associated scaffolding protein that interacts with microtubule motors as well as actin-associated adaptor molecules. We examined a role for Htt in the dynein-mediated intracellular trafficking of endosomes and lysosomes. In HeLa cells depleted of either Htt or dynein,...

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Autors principals: Caviston, Juliane P., Zajac, Allison L., Tokito, Mariko, Holzbaur, Erika L.F.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038646/
https://ncbi.nlm.nih.gov/pubmed/21169558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-03-0233
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