Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?

The pharmacokinetics (PK) of therapeutic antibodies is determined by target and non-target mediated mechanisms. These antibody-specific factors need to be considered during prediction of human PK based upon preclinical information. Principles of allometric scaling established for small molecules usi...

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Bibliografske podrobnosti
Main Authors: Deng, Rong, Iyer, Suhasini, Theil, Frank-Peter, Mortensen, Deborah L, Fielder, Paul J, Prabhu, Saileta
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038012/
https://ncbi.nlm.nih.gov/pubmed/20962582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.1.13799
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