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Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells.

We have examined the effects of menadione on porcine aortic endothelial cell prostaglandin synthesis. Addition of 1-20 microM menadione caused a dose- and time-dependent inhibition of stimulated prostaglandin synthesis with an IC50 of 5 microM at 15 min. Concentrations greater than 100 microM menadi...

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Détails bibliographiques
Auteurs principaux: Barchowsky, A, Tabrizi, K, Kent, R S, Whorton, A R
Format: Artigo
Langue:Inglês
Publié: 1989
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC303801/
https://ncbi.nlm.nih.gov/pubmed/2495300
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