Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R

Mutations in human copper-zinc superoxide dismutase (SOD1) cause an inherited form of the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS). Here, we present structures of the pathogenic SOD1 variants D124V and H80R, both of which demonstrate compromised zinc-binding sites. The dis...

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Autores principales: Seetharaman, Sai V., Winkler, Duane D., Taylor, Alexander B., Cao, Xiaohang, Whitson, Lisa J., Doucette, Peter A., Valentine, Joan S., Schirf, Virgil, Demeler, Borries, Carroll, Mark C., Culotta, Valeria C., Hart, P. John
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037816/
https://ncbi.nlm.nih.gov/pubmed/20515040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100314n
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