Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R

Mutations in human copper-zinc superoxide dismutase (SOD1) cause an inherited form of the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS). Here, we present structures of the pathogenic SOD1 variants D124V and H80R, both of which demonstrate compromised zinc-binding sites. The dis...

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Detalhes bibliográficos
Main Authors: Seetharaman, Sai V., Winkler, Duane D., Taylor, Alexander B., Cao, Xiaohang, Whitson, Lisa J., Doucette, Peter A., Valentine, Joan S., Schirf, Virgil, Demeler, Borries, Carroll, Mark C., Culotta, Valeria C., Hart, P. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037816/
https://ncbi.nlm.nih.gov/pubmed/20515040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100314n
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