The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

The multiple myeloma SET domain (MMSET) protein is overexpressed in multiple myeloma (MM) patients with the translocation t(4;14). Although studies have shown the involvement of MMSET/Wolf-Hirschhorn syndrome candidate 1 in development, its mode of action in the pathogenesis of MM is largely unknown...

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Autors principals: Martinez-Garcia, Eva, Popovic, Relja, Min, Dong-Joon, Sweet, Steve M. M., Thomas, Paul M., Zamdborg, Leonid, Heffner, Aaron, Will, Christine, Lamy, Laurence, Staudt, Louis M., Levens, David L., Kelleher, Neil L., Licht, Jonathan D.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037745/
https://ncbi.nlm.nih.gov/pubmed/20974671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-298349
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