Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells

The PI3K/Akt pathway is activated in stimulated cells and in many cancers to promote glucose metabolism and prevent cell death. Although inhibition of Akt-mediated cell survival may provide a means to eliminate cancer cells, this survival pathway remains incompletely understood. In particular, unlik...

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Bibliografische gegevens
Hoofdauteurs: Coloff, Jonathan L., Mason, Emily F., Altman, Brian J., Gerriets, Valerie A., Liu, Tingyu, Nichols, Amanda N., Zhao, Yuxing, Wofford, Jessica A., Jacobs, Sarah R., Ilkayeva, Olga, Garrison, Sean P., Zambetti, Gerard P., Rathmell, Jeffrey C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037705/
https://ncbi.nlm.nih.gov/pubmed/21159778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179101
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