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A Two-step Binding Model of PCSK9 Interaction with the Low Density Lipoprotein Receptor

PCSK9 (proprotein convertase subtilisin-like/kexin type 9) is an emerging target for pharmaceutical intervention. This multidomain protein interacts with the LDL receptor (LDLR), promoting receptor degradation. Insofar as PCSK9 inhibition induces a decrease in plasma cholesterol levels, understandin...

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Detalhes bibliográficos
Main Authors: Yamamoto, Taichi, Lu, Christine, Ryan, Robert O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037659/
https://ncbi.nlm.nih.gov/pubmed/21149300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199042
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