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A Two-step Binding Model of PCSK9 Interaction with the Low Density Lipoprotein Receptor
PCSK9 (proprotein convertase subtilisin-like/kexin type 9) is an emerging target for pharmaceutical intervention. This multidomain protein interacts with the LDL receptor (LDLR), promoting receptor degradation. Insofar as PCSK9 inhibition induces a decrease in plasma cholesterol levels, understandin...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037659/ https://ncbi.nlm.nih.gov/pubmed/21149300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199042 |
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