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Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor
PCSK9 (proprotein convertase subtilisin/kexin type 9) promotes degradation of the LDLR [LDL (low-density lipoprotein) receptor] through an as-yet-undefined mechanism, leading to a reduction in cellular LDLc (LDL-cholesterol) and a concomitant increase in serum LDLc. Central to the function of PCSK9...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669217/ https://ncbi.nlm.nih.gov/pubmed/19196236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20082407 |
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