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Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that controls plasma LDL cholesterol levels by posttranslational regulation of the LDL receptor (LDLR). Previously, we showed that PCSK9 binds specifically to an EGF-like repeat (EGF-A) in LDLR and reroutes the receptor from...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2526098/ https://ncbi.nlm.nih.gov/pubmed/18753623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806312105 |
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