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Molecular and Structural Insight for the Role of Key Residues of Thrombospondin-1 and Calreticulin in Thrombospondin-1-Calreticulin Binding

Thrombospondin-1 (TSP1) binding to calreticulin (CRT) on the cell surface signals focal adhesion disassembly leading to the intermediate adhesive phenotype, cell migration, anoikis resistance, and collagen stimulation. Residues Lys 24 and 32 in TSP1 and amino acids 24-26 and 32-34 in CRT have been s...

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Autores principales: Yan, Qi, Murphy-Ullrich, Joanne E., Song, Yuhua
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037594/
https://ncbi.nlm.nih.gov/pubmed/21142150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101639y
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