Enhanced Active Cross-Bridges during Diastole: Molecular Pathogenesis of Tropomyosin's HCM Mutations

Three HCM-causing tropomyosin (Tm) mutants (V95A, D175N, and E180G) were examined using the thin-filament extraction and reconstitution technique. The effects of Ca(2+), ATP, phosphate, and ADP concentrations on cross-bridge kinetics in myocardium reconstituted with each of these mutants were studie...

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Main Authors: Bai, Fan, Weis, Adam, Takeda, Aya K., Chase, P. Bryant, Kawai, Masataka
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2011
Teme:
Muscle, Motility, and Motor Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037557/
https://ncbi.nlm.nih.gov/pubmed/21320446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.001
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