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Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

A recently described peptide hormone, endothelin, is a potent vasoconstrictor, but it is unclear whether endothelin has other biological actions. These experiments extend the range of biological actions of endothelin to stimulation of mitogenesis. Endothelin at low concentrations (0.1-10 nM) induced...

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Publicat a:J Clin Invest
Autors principals: Simonson, M S, Wann, S, Mené, P, Dubyak, G R, Kester, M, Nakazato, Y, Sedor, J R, Dunn, M J
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1989
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303732/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536405/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113935
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