Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: Relevance to valproate’s efficacy against bipolar disorder

BACKGROUND: The ability of chronic valproate (VPA) to reduce arachidonic acid (AA) turnover in brain phospholipids of unanesthetized rats has been ascribed to its inhibition of acyl-CoA synthetase (Acsl)-mediated activation of AA to AA-CoA. Our aim was to identify a rat Acsl isoenzyme that could be...

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Hlavní autoři: Shimshoni, Jakob A., Basselin, Mireille, Li, Lei O., Coleman, Rosalind A., Rapoport, Stanley I., Modi, Hiren R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037030/
https://ncbi.nlm.nih.gov/pubmed/21184843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2010.12.006
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