Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

We investigated the actions of endothelin in anesthetized rats and cultured mesangial cells. Intravenous infusion of endothelin (10 pmol/min) decreased renal blood flow by 44% at 20 min without changing arterial pressure, which subsequently rose significantly from 124 +/- 3 to 133 +/- 4 mmHg over 60...

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Bibliographic Details

Published in:	J Clin Invest
Main Authors:	Badr, K F, Murray, J J, Breyer, M D, Takahashi, K, Inagami, T, Harris, R C
Format:	Artigo
Language:	Inglês
Published:	American Society for Clinical Investigation 1989
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536045/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113880
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