Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

We investigated the actions of endothelin in anesthetized rats and cultured mesangial cells. Intravenous infusion of endothelin (10 pmol/min) decreased renal blood flow by 44% at 20 min without changing arterial pressure, which subsequently rose significantly from 124 +/- 3 to 133 +/- 4 mmHg over 60...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Badr, K F, Murray, J J, Breyer, M D, Takahashi, K, Inagami, T, Harris, R C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536045/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113880
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