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Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
Chronic myeloid leukemia (CML) results from expression of the BCR/ABL oncogene in a primitive hematopoietic cell. However BCR/ABL-activated signaling mechanisms are dependent on the cellular context in which it is expressed, and mechanisms underlying primitive human hematopoietic cell transformation...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3036781/ https://ncbi.nlm.nih.gov/pubmed/21072043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.257 |
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