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The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains an important challenge in pediatric oncology. Because of the particularly poor prognosis of relapses, it is vital to identify molecular risk factors allowing early and effective treatment stratification. Activating NOTCH1 mutations signif...

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Detalhes bibliográficos
Main Authors: Kox, C, Zimmermann, M, Stanulla, M, Leible, S, Schrappe, M, Ludwig, W-D, Koehler, R, Tolle, G, Bandapalli, O R, Breit, S, Muckenthaler, M U, Kulozik, A E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035973/
https://ncbi.nlm.nih.gov/pubmed/20944675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.203
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