Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants

The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered a promising anticancer therapeutic agent. As apoptosis seems to occur prim...

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Detalhes bibliográficos
Main Authors: Reis, C R, van der Sloot, A M, Natoni, A, Szegezdi, E, Setroikromo, R, Meijer, M, Sjollema, K, Stricher, F, Cool, R H, Samali, A, Serrano, L, Quax, W J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035906/
https://ncbi.nlm.nih.gov/pubmed/21368856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.61
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