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DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since not all pancreatic cancer cells respond to TRAIL, further improvements and optim...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Yu, Rui, Albarenque, Stella Maris, Cool, Robbert H, Quax, Wim J, Mohr, Andrea, Zwacka, Ralf M
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623120/
https://ncbi.nlm.nih.gov/pubmed/25482930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.972183
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