Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects

Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells...

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Detalles Bibliográficos
Main Authors: Yu, R, Deedigan, L, Albarenque, S M, Mohr, A, Zwacka, R M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734822/
https://ncbi.nlm.nih.gov/pubmed/23429289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.19
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