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Molecular mechanism by which palmitate inhibits PKR autophosphorylation

PKR (double-stranded RNA-activated protein kinase) is an important component of the innate immunity, antiviral and apoptotic pathways. Recently, our group found that palmitate, a saturated fatty acid, is involved in apoptosis by reducing the autophosphorylation of PKR at the Thr451 residue, however,...

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Detalhes bibliográficos
Main Authors: Cho, Hyunju, Mukherjee, Shayantani, Palasuberniam, Pratheeba, Pillow, Lisa, Bilgin, Betul, Nezich, Catherine, Walton, S. Patrick, Feig, Michael, Chan, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035770/
https://ncbi.nlm.nih.gov/pubmed/21192654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101923r
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