Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophils.

Human neutrophils, when stimulated with phorbol myristate acetate or fMet-Leu-Phe in the presence or absence of cytochalasin B, released metalloproteinases that catalytically inactivated the plasma serine proteinase inhibitor, alpha 1-antitrypsin. Inactivation, measured as loss of elastase inhibitor...

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Autors principals: Vissers, M C, George, P M, Bathurst, I C, Brennan, S O, Winterbourn, C C
Format: Artigo
Idioma:Inglês
Publicat: 1988
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC303567/
https://ncbi.nlm.nih.gov/pubmed/2841359
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