Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophils.

Human neutrophils, when stimulated with phorbol myristate acetate or fMet-Leu-Phe in the presence or absence of cytochalasin B, released metalloproteinases that catalytically inactivated the plasma serine proteinase inhibitor, alpha 1-antitrypsin. Inactivation, measured as loss of elastase inhibitor...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Vissers, M C, George, P M, Bathurst, I C, Brennan, S O, Winterbourn, C C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303567/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2841359/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113651
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