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Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis

The “lipotoxic footprint” of cardiac maladaptation in diet-induced obesity is poorly defined. We investigated how manipulation of dietary lipid and carbohydrate influenced potential lipotoxic species in the failing heart. In Wistar rats, contractile dysfunction develops at 48 weeks on a high-fat/hig...

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Detalhes bibliográficos
Main Authors: Harmancey, Romain, Wilson, Christopher R., Wright, Nathan R., Taegtmeyer, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035501/
https://ncbi.nlm.nih.gov/pubmed/20093477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M001230
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