Different modes of interaction by TIAR and HuR with target RNA and DNA

TIAR and HuR are mRNA-binding proteins that play important roles in the regulation of translation. They both possess three RNA recognition motifs (RRMs) and bind to AU-rich elements (AREs), with seemingly overlapping specificity. Here we show using SPR that TIAR and HuR bind to both U-rich and AU-ri...

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Autori principali: Kim, Henry S., Wilce, Matthew C. J., Yoga, Yano M. K., Pendini, Nicole R., Gunzburg, Menachem J., Cowieson, Nathan P., Wilson, Gerald M., Williams, Bryan R. G., Gorospe, Myriam, Wilce, Jacqueline A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035456/
https://ncbi.nlm.nih.gov/pubmed/21233170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq837
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