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Poly(oligo--arginine) With Internal Disulfide Linkages as a Cytoplasm-sensitive Carrier for siRNA Delivery
Small interfering RNA (siRNA) has emerged as a therapeutic strategy for various diseases due to its target-specific gene silencing; however, its relatively high molecular weight, negative charge, and low stability hamper in vitro and in vivo applications. Approaches to overcome those drawbacks have...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034849/ https://ncbi.nlm.nih.gov/pubmed/21081902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.242 |
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