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Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action

Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory loss, inability to perform the activities of daily living and personality changes. Unfortunately, drugs effective for this disease are limited to acetylcholinesterase inhibitors that do not impact...

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Detalhes bibliográficos
Main Authors: Barone, Eugenio, Cenini, Giovanna, Di Domenico, Fabio, Martin, Sarah, Sultana, Rukhsana, Mancuso, Cesare, Murphy, Michael Paul, Head, Elizabeth, Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034810/
https://ncbi.nlm.nih.gov/pubmed/21193043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2010.12.007
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