Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T(H)17 to Regulatory T Cells in HIV Disease

The pathogenesis of human and simian immunodeficiency viruses is characterized by CD4(+) T cell depletion and chronic T cell activation, leading ultimately to AIDS. CD4(+) T helper (T(H)) cells provide protective immunity and immune regulation through different immune cell functional subsets, includ...

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Detalhes bibliográficos
Main Authors: Favre, David, Mold, Jeff, Hunt, Peter W., Kanwar, Bittoo, Loke, P’ng, Seu, Lillian, Barbour, Jason D., Lowe, Margaret M., Jayawardene, Anura, Aweeka, Francesca, Huang, Yong, Douek, Daniel C., Brenchley, Jason M., Martin, Jeffrey N., Hecht, Frederick M., Deeks, Steven G., McCune, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034445/
https://ncbi.nlm.nih.gov/pubmed/20484731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000632
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