Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice

Indoleamine 2,3-dioxygenase (IDO) is one of the initial and rate-limiting enzymes involved in the catabolism of the essential amino acid tryptophan. In cultured cells, the induction of IDO leads to depletion of tryptophan and tryptophan starvation. Recent studies suggest that modulation of tryptopha...

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Detalhes bibliográficos
Main Authors: Szántó, Sándor, Koreny, Tamás, Mikecz, Katalin, Glant, Tibor T, Szekanecz, Zoltán, Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206348/
https://ncbi.nlm.nih.gov/pubmed/17511858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2205
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