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Dihydrosphingosine-1 phosphate has a potent anti-fibrotic effect in Scleroderma fibroblasts via normalization of PTEN levels
OBJECTIVE: Previous studies have uncovered a PTEN-dependent interaction between the sphingolipid agonist, dhS1P, and the TGF-β/Smad3 signaling pathway. Here we sought to examine responses of SSc fibroblasts to S1P and dhS1P and to gain further insight into the regulation of the S1P/dhS1P/PTEN pathwa...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034368/ https://ncbi.nlm.nih.gov/pubmed/20309867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27463 |
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