Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

Rimonabant, the prototypic antagonist of cannabinoid CB(1) receptors, has been reported to have inverse agonist properties at higher concentrations, which may complicate its use as a tool for mechanistic evaluation of cannabinoid pharmacology. Consequently, recent synthesis efforts have concentrated...

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Detalhes bibliográficos
Main Authors: Wiley, Jenny L., Breivogel, Christopher S., Mahadevan, Anu, Pertwee, Roger G., Cascio, Maria Grazia, Bolognini, Daniele, Huffman, John W., Walentiny, D. Matthew, Vann, Robert E., Razdan, Raj K., Martin, Billy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034309/
https://ncbi.nlm.nih.gov/pubmed/21114999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.10.085
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