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Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist
Rimonabant, the prototypic antagonist of cannabinoid CB(1) receptors, has been reported to have inverse agonist properties at higher concentrations, which may complicate its use as a tool for mechanistic evaluation of cannabinoid pharmacology. Consequently, recent synthesis efforts have concentrated...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034309/ https://ncbi.nlm.nih.gov/pubmed/21114999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.10.085 |
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