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The Role of Fluorine Substitution in the Structure-Activity Relationships (SAR) of Classical Cannabinoids.
A facile synthesis of 1-fluoro-1-deoxy-Δ8-THC analogs with side-chains seven carbons in length, in the alkane/ene/yne-series (6, 5 and 4), was achieved from 1-fluoro-3,5-dimethoxybenzene (1). In vitro studies show that substitution by a fluorine has a significant detrimental effect on CB1 binding wh...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855243/ https://ncbi.nlm.nih.gov/pubmed/17257842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.01.006 |
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