Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response

BACKGROUND: 1-{4-[Bis(2-chloroethyl)amino]phenyl}-3-[2-methyl-5-(4-methylacridin-9-ylamino)phenyl]urea (BO-1051) is an N-mustard DNA alkylating agent reported to exhibit antitumor activity. Here we further investigate the effects of this compound on radiation responses of human gliomas, which are no...

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Autors principals: Chu, Pei-Ming, Chiou, Shih-Hwa, Su, Tsann-Long, Lee, Yi-Jang, Chen, Li-Hsin, Chen, Yi-Wei, Yen, Sang-Hue, Chen, Ming-Teh, Chen, Ming-Hsiung, Shih, Yang-Hsin, Tu, Pang-Hsien, Ma, Hsin-I
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033832/
https://ncbi.nlm.nih.gov/pubmed/21244709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-6-7
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