Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response

BACKGROUND: 1-{4-[Bis(2-chloroethyl)amino]phenyl}-3-[2-methyl-5-(4-methylacridin-9-ylamino)phenyl]urea (BO-1051) is an N-mustard DNA alkylating agent reported to exhibit antitumor activity. Here we further investigate the effects of this compound on radiation responses of human gliomas, which are no...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chu, Pei-Ming, Chiou, Shih-Hwa, Su, Tsann-Long, Lee, Yi-Jang, Chen, Li-Hsin, Chen, Yi-Wei, Yen, Sang-Hue, Chen, Ming-Teh, Chen, Ming-Hsiung, Shih, Yang-Hsin, Tu, Pang-Hsien, Ma, Hsin-I
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2011
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033832/
https://ncbi.nlm.nih.gov/pubmed/21244709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-6-7
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