The Fate and Function of Therapeutic Antiaddiction Monoclonal Antibodies across the Reproductive Cycle of Rats

During preclinical development of neuroprotective antiaddiction therapeutic monoclonal antibodies (mAbs) against phencyclidine (PCP) and (+)-methamphetamine, we discovered novel, gestation stage-specific changes in mAb disposition spanning the entire reproductive cycle of female rats. Each pharmacol...

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Bibliographic Details
Main Authors: Hubbard, Jonathan J., Laurenzana, Elizabeth M., Williams, D. Keith, Gentry, W. Brooks, Owens, S. Michael
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033712/
https://ncbi.nlm.nih.gov/pubmed/20962030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175083
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