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Ethanol Induction of CYP2A5: Permissive Role for CYP2E1

CYP2A5 metabolizes xenobiotics and activates hepatocarcinogens, and induction occurs in response to hepatic damage and cellular stress. We evaluated whether ethanol can elevate CYP2A5 and whether CYP2E1 plays a role in the ethanol induction of CYP2A5. Wild-type (WT), CYP2E1 knockout (KO), and CYP2E1...

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Detalhes bibliográficos
Main Authors: Lu, Yongke, Zhuge, Jian, Wu, Defeng, Cederbaum, Arthur I.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033694/
https://ncbi.nlm.nih.gov/pubmed/21051534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035691
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