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mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to regulate cell growth (increased cell mass and cell size) and cell division. The immunosuppressive drug rapamycin inhibits cell cycle progression via inhibition of mTOR; however, the signaling pathways by which mTOR r...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Principais autores: Fingar, Diane C., Richardson, Celeste J., Tee, Andrew R., Cheatham, Lynn, Tsou, Christina, Blenis, John
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303352/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14673156/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.1.200-216.2004
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