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Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian Cytochrome P450

Resonance Raman (RR) spectroscopy is used to help define active site structural responses of nanodisc-incorporated CYP3A4 to the binding of three substrates; bromocriptine (BC), erythromycin (ERY) and testosterone (TST). We demonstrate that nanodisc-incorporated assemblies reveal much more well-defi...

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Bibliografiske detaljer
Main Authors: Mak, Piotr J., Denisov, Ilia G., Grinkova, Yelena V., Sligar, Stephen G., Kincaid, James R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033474/
https://ncbi.nlm.nih.gov/pubmed/21207936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105869p
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