Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins

Proteasome-mediated protein degradation has been implicated in playing a role in nuclear receptor-mediated gene expression; inhibition of the proteasome impairs the transcriptional activity of estrogen receptor α (ERα) and most other nuclear receptors. This coincides with blockage of agonist-depende...

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Detaylı Bibliyografya

Yayımlandı:	Mol Cell Biol
Asıl Yazarlar:	Lonard, David M., Tsai, Sophia Y., O'Malley, Bert W.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Taylor & Francis 2004
Konular:	Transcriptional Regulation
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303341/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14673139/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.1.14-24.2004
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