Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins

Proteasome-mediated protein degradation has been implicated in playing a role in nuclear receptor-mediated gene expression; inhibition of the proteasome impairs the transcriptional activity of estrogen receptor α (ERα) and most other nuclear receptors. This coincides with blockage of agonist-depende...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Biol
Autori principali: Lonard, David M., Tsai, Sophia Y., O'Malley, Bert W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2004
Soggetti:
Transcriptional Regulation
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303341/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14673139/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.1.14-24.2004
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