Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ(12,14)-Prostaglandin J(2)

Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes. In this study, we examined how Nrf2 contributes to the anti-inflammatory process. As a model system of acute inflammation, we administered...

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Main Authors: Itoh, Ken, Mochizuki, Mie, Ishii, Yukio, Ishii, Tetsuro, Shibata, Takahiro, Kawamoto, Yoshiyuki, Kelly, Vincent, Sekizawa, Kiyohisa, Uchida, Koji, Yamamoto, Masayuki
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Transcriptional Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC303336/
https://ncbi.nlm.nih.gov/pubmed/14673141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.36-45.2004
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