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A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy

Polymorphisms in the human endothelial nitric oxide synthase (eNOS) gene (NOS3) have been associated with advanced nephropathy in diabetic patients and with decreased expression in tissue culture. However, direct proof that modest genetic decreases in eNOS expression worsen diabetic nephropathy is l...

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Detalhes bibliográficos
Main Authors: Wang, Chih-Hong, Li, Feng, Hiller, Sylvia, Kim, Hyung-Suk, Maeda, Nobuyo, Smithies, Oliver, Takahashi, Nobuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033253/
https://ncbi.nlm.nih.gov/pubmed/21245338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018766108
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